High-resolution x-ray 3D imaging of bone micro-structure
Osteoporosis impact on public health is sharply increasing justifying a significant effort to diagnose, reat and understand this disease. Bones have been imaged with x-rays for almost a century and the basic technology for clinical image is well established, but with the recent development of large scale synchrotron light sources and high-end microfiches x-ray generators, imaging of the intricate bone inner structure with a few micron resolution become possible. Laser driven betatron x-ray microscope was built and used to demonstrate the feasibility of high-resolution bone imaging in the Astra-Gemini laser facility (UK). A sample of femur trabecular bone was imaged from multiple angles and a 3D model of the bone was built using tomographic techniques to a resolution below 50 micron. This demonstration renew the interest in the development of compact laser-plasma electron accelerators and its applications. It also opens prospects for its use in clinic diagnostics in the medium term.
Welcome to the website of the X-GoLP team, the experimental team of the Group for Lasers and Plasmas of the Instituto de Plasmas e Fusão Nuclear at Instituto Superior Técnico.
Luís Braga defended successfully his MSc thesis on November 23, being awarded a final grade of 18/20.In his work, Luís evaluates the role of beam collimation at the input of a large aperture, single-pass grating compressor. The experimental setup investigated is the compressor at Vulcan’s laser Target Area West.An analytical model for space-time pulse propagation was developed, which adequately explains the influence of beam…
The 2018 Nobel Prize in Physics was awarded to Arthur Ashkin for “optical tweezers and their application to biological systems” and to Gérard Mourou and Donna Strickland for “their method of generating high-intensity, ultra-short optical pulses”. Mourou and Strickland invented the Chirped Pulse Amplification method (CPA) thirty year ago. The CPA method is used to amplify ultra-short laser pulses (from picosecond to femtosecond). The…
Compact laser accelerators for X-ray phase-contrast imaging, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A: MATHEMATICAL, PHYSICAL AND ENGINEERING SCIENCES 372 (2014) p. 20130032Z. Najmudin , S. Kneip , M. S. Bloom , S. P. D. Mangles , O. Chekhlov , A. E. Dangor , A. Döpp , K. Ertel , S. J. Hawkes , J. Holloway , C. J. Hooker , J. Jiang , N. C. Lopes , H. Nakamura , P. A. Norreys , P. P. Rajeev , C. Russo , M. J. V. Streeter , D. R. Symes , and M. Wing