High-resolution x-ray 3D imaging of bone micro-structure
Osteoporosis impact on public health is sharply increasing justifying a significant effort to diagnose, reat and understand this disease. Bones have been imaged with x-rays for almost a century and the basic technology for clinical image is well established, but with the recent development of large scale synchrotron light sources and high-end microfiches x-ray generators, imaging of the intricate bone inner structure with a few micron resolution become possible. Laser driven betatron x-ray microscope was built and used to demonstrate the feasibility of high-resolution bone imaging in the Astra-Gemini laser facility (UK). A sample of femur trabecular bone was imaged from multiple angles and a 3D model of the bone was built using tomographic techniques to a resolution below 50 micron. This demonstration renew the interest in the development of compact laser-plasma electron accelerators and its applications. It also opens prospects for its use in clinic diagnostics in the medium term.
Welcome to the website of the X-GoLP team, the experimental team of the Group for Lasers and Plasmas of the Instituto de Plasmas e Fusão Nuclear at Instituto Superior Técnico.
Mario Galletti defended successfully his PhD thesis on June 4, 2020, being awarded the top final grade of Approved with Distinction Cum Laude.
During his PhD, Mario worked on different topics ranging from optical parametric oscillators and amplifiers, laser-matter interaction and laser and plasma diagnostics. He performed research at the Laboratory for Intense Lasers, IST, at the VULCAN laser, Central Laser Facility (UK) and at…